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KMID : 0367320130240010021
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2013 Volume.24 No. 1 p.21 ~ p.27
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Regional Brain Perfusion before and after Treatment with Methylphenidate According to the MspI Polymorphism of the Alpha-2A Adrenergic Receptor Gene in Children with Attention-Deficit Hyperactivity Disorder
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Park Su-Bin
Bae Jeong-Hoon
Kim Jae-Won
Yang Young-Hui
Oh Seung-Min
Hong Soon-Beom
Park Min-Hyeon
Kim Bung-Nyun
Shin Min-Sup
Yoo Hee-Jeong
Cho Soo-Churl
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Abstract
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Objectives : Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD.
Methods : Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated.
Results : No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype.
Conclusion : Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.
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KEYWORD
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Attention-Deficit Hyperactivity Disorder, ADRA2A, Single-Photon Emission Computed Tomography, Pharmacogenetics
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